CD154 Activates Macrophage Antimicrobial Activity in the Absence of IFN- through a TNF- -Dependent Mechanism
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CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon.
CD40-CD154 interaction is pivotal for resistance against numerous pathogens. However, it is not known if this pathway can also enhance in vivo resistance in gamma interferon (IFN-gamma)-deficient hosts. This is an important question because patients and mice with defects in type 1 cytokine response can control a variety of pathogens. While blockade of endogenous CD154 resulted in a remarkable i...
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